Publications by authors named "S Giaglis"
Article Synopsis
- The blood-labyrinth barrier (BLB) is crucial for maintaining the ionic balance in the inner ear and preventing harmful substances from entering.
- Recent studies have shown that dysregulation of BLB permeability is linked to various auditory issues, such as acoustic trauma and autoimmune diseases.
- This study found that neutrophil extracellular traps (NETs) affect endothelial cells in the BLB, leading to increased permeability and changes in cell structure, suggesting a need for further research on NETs' role in auditory disorders.
Platelets are crucial for thrombosis and hemostasis. Importantly, they contain mitochondria that are responsible for energy generation and therefore vital for platelet survival and activation. Activated platelets can release mitochondria that may be free or encapsulated in platelet extracellular vesicles (EVs).
View Article and Find Full Text PDFObjectives: Neutrophil extracellular trap formation and cell-free DNA (cfDNA) contribute to the inflammation in rheumatoid arthritis (RA), but it is unknown if mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) is more abundant in the circulation. It is unclear if DNA concentration measurements may assist in clinical decision-making.
Methods: This single-center prospective observational study collected plasma from consecutive RA patients and healthy blood donors.
Objectives: ANCA-associated vasculitis (AAV) includes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). ANCA triggers neutrophil extracellular trap formation, which releases either mitochondrial (mt) DNA or nuclear DNA (n) DNA, contributing to inflammation. Our aim was to prospectively examine the extent and nature of circulating DNA in AAV and the clinical utility of DNA quantification.
View Article and Find Full Text PDF