Publications by authors named "S Ghatan"
We aimed to: (1) examine the relationship between glycemic control, BMD estimated from heel ultrasound (eBMD) and fracture risk in individuals with type 1 (T1D) and type 2 diabetes (T2D) and (2) perform a one-sample Mendelian randomization (MR) study to explore potential causal associations between glycemic control, eBMD, and fractures. This study comprised 452 131 individuals from the UK Biobank with glycated hemoglobin A1C (HbA) and eBMD levels. At baseline, 4078 participants were diagnosed with T1D and 23 682 with T2D.
View Article and Find Full Text PDFObjective: Thoracic dorsal arachnoid webs are intradural membranes that may cause obstruction of cerebrospinal fluid flow and spinal cord compression. Although well recognized, they are rare and there is a paucity of long-term data on their natural history and prognosis. We reviewed radiographic features, surgical indications, and pathologic specimens of patients diagnosed with focal thoracic dorsal arachnoid webs.
View Article and Find Full Text PDFArticle Synopsis
- - The case study discusses a 24-year-old male with tuberous sclerosis complex (TSC) who achieved significant seizure control after receiving a responsive neurostimulation (RNS) device, despite it being generally regarded as a palliative option for drug-resistant epilepsy (DRE).
- - Before the RNS implantation, the patient underwent multiple surgical procedures and treatments but continued to experience frequent seizures. Initially, the RNS reduced his seizures, but after a lead revision, he became seizure-free for nearly 3 years, with only a couple of breakthrough seizures later on.
- - The findings suggest that RNS could be an effective treatment for epilepsy in TSC patients when other treatments have failed, indicating that this therapy should be
Article Synopsis
- * Sarcopenia (muscle loss) and osteoporosis (bone loss) are closely linked, with each condition serving as a predictor for the other, indicating the need for integrated research approaches.
- * A recent workshop emphasized the importance of muscle characterization in musculoskeletal studies, advocating for more recognition and research on muscle phenotyping in both human and animal models like zebrafish and mice.
Genomic loci associated with common traits and diseases are typically non-coding and likely impact gene expression, sometimes coinciding with rare loss-of-function variants in the target gene. However, our understanding of how gradual changes in gene dosage affect molecular, cellular, and organismal traits is currently limited. To address this gap, we induced gradual changes in gene expression of four genes using CRISPR activation and inactivation.
View Article and Find Full Text PDF