Automatic (near-) duplicate content document detection in a cancer registry.

Background: Duplicate and near-duplicate medical documents are problematic in document management, clinical use, and medical research. In this study, we focus on multisourced medical documents in the context of a population-based cancer registry in Switzerland. Although the data collection process is well-regulated, the volume of transmitted documents steadily increases and the presence of full or near-duplicates slows down and complicates document processing.

Debottlenecking cytochrome P450-dependent metabolic pathways for the biosynthesis of commercial natural products.

Covering: 2016 to the end of 2024This highlight article aims to provide a perspective on the challenges that novel biotechnological processes face in the biomanufacturing of natural products (NPs) whose biosynthesis pathways rely on cytochrome P450 monooxygenases. This enzyme superfamily is one of the most versatile in the biosynthesis of a plethora of NPs finding use across the food, nutrition, medicine, chemical and cosmetics industries. These enzymes often exhibit excellent regio- and stereoselectivity, but they can suffer from low activity and instability, which are serious issues impairing the development of high performing bioprocesses.

Long-term outcomes in patients with Cushing's disease vs nonfunctioning pituitary adenoma after pituitary surgery: an active-comparator cohort study.

Objective: There is increasing evidence that multisystem morbidity in patients with Cushing's disease (CD) is only partially reversible following treatment. We investigated complications from multiple organs in hospitalized patients with CD compared to patients with nonfunctioning pituitary adenoma (NFPA) after pituitary surgery.

Design: Population-based retrospective cohort study using data from the Swiss Federal Statistical Office between January 2012 and December 2021.

The effect of tube quality on externally calibrated quantitative nuclear magnetic resonance analysis: How bad can it be?

Externally calibrated quantitative nuclear magnetic resonance (NMR) approaches offer practical means to simultaneously evaluate chemical identity and content without the addition of calibrants to the test sample. Despite continuous advances in external calibration over the last few decades, adoption of these approaches has been slower than expected. Variations in NMR tube geometry are a commonly overlooked factor that can have a substantial effect on externally calibrated quantitation methods.