Publications by authors named "S Gerhard"
Article Synopsis
- Animal movement is directed by motor neurons that connect the central nervous system to muscles, with complex premotor networks coordinating these movements for various behaviors.
- Researchers analyzed the wiring of premotor circuits in Drosophila flies to understand how motor networks control leg and wing movements.
- They discovered that leg motor modules have a hierarchical structure based on the size of motor neurons, while wing circuits are more flexible in their connectivity, highlighting differences in motor control for distinct body parts.
Article Synopsis
- This study focuses on understanding how neural circuits in the brain manage behavior by analyzing the Drosophila melanogaster (fruit fly) ventral nerve cord, which mirrors the spinal cord in vertebrates.
- Researchers mapped approximately 45 million synapses and 14,600 neuron cell bodies within the fruit fly's nerve cord to comprehend its neural connections.
- They created a motor neuron atlas that identifies which muscles are targeted by motor neurons, aiding in the understanding of leg and wing movement coordination, especially during take-off.
Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles. MN activity is coordinated by complex premotor networks that allow individual muscles to contribute to many different behaviors. Here, we use connectomics to analyze the wiring logic of premotor circuits controlling the leg and wing.
View Article and Find Full Text PDFPurpose: Organ at risk (OAR) dose constraints are a critical aspect of SABR treatment planning. There is limited evidence supporting preferred dose constraints for many OARs. We sought to evaluate OAR dose constraints used in ongoing clinical trials of SABR for oligometastatic disease.
View Article and Find Full Text PDFWe develop an automatic method for synaptic partner identification in insect brains and use it to predict synaptic partners in a whole-brain electron microscopy dataset of the fruit fly. The predictions can be used to infer a connectivity graph with high accuracy, thus allowing fast identification of neural pathways. To facilitate circuit reconstruction using our results, we develop CIRCUITMAP, a user interface add-on for the circuit annotation tool CATMAID.
View Article and Find Full Text PDF