Publications by authors named "S George Pemberton"
There are genetic and environmental risk factors that contribute to the development of cognitive decline in Alzheimer's disease (AD). Some of these include the genetic predisposition of the apolipoprotein E4 genotype, consuming a high-fat diet (HFD), and the female sex. Brain insulin receptor resistance and deficiency have also been shown to be associated with AD and cognitive impairment.
View Article and Find Full Text PDFOsteosarcoma with widespread metastasis in a 1-year-old crossbred rabbit.
Vet Radiol Ultrasound
September 2024
A 14-month-old female spayed, small crossbred rabbit presented for assessment of a small, hard subcutaneous nodule in the right axilla. Serum biochemistry showed markedly increased serum ALP activity. A whole-body CT revealed an aggressive, monostotic osteolytic, and productive lesion within the left alveolar process of the maxilla, with erosion of the alveolar bone and secondary premolar depression.
View Article and Find Full Text PDFArticle Synopsis
- Insulin moves from the blood to the brain through a special barrier called the blood-brain barrier (BBB), and this process can be affected by different factors like insulin levels and fats in the body.
- In a study with healthy mice, scientists looked at how changing insulin levels in the brain affected its transport across the BBB.
- They discovered that more insulin in the brain actually lowered how much insulin could get through the BBB, indicating that the brain controls how insulin is taken up, and this may relate to issues seen in Alzheimer's disease.
Lupus Interference With B Cell Tolerance Across the Developmental Continuum.
Arthritis Rheumatol
September 2023