Publications by authors named "S Genovese"
Study Design: Systematic Review Study.
Objectives: The objective of this study is to assess the cost-effectiveness and cost-utility of rhBMP-2 in spine surgeries.
Methods: PubMed, MEDLINE, OVID and CENTRAL (Cochrane Central Register of Controlled Trials) databases were systematically searched for studies reporting the use of rhBMP-2 for spinal procedures in comparison to autograft and/or allograft and alternative graft materials under consideration of cost-effectiveness, cost-benefit, cost minimization, and/or cost-utility analysis.
Pembrolizumab (Keytruda), an immune checkpoint inhibitor, has been increasingly utilized in the treatment of metastatic urothelial carcinoma. While offering a favorable safety profile compared to traditional chemotherapy, it presents unique risks, including immune-related adverse events (irAEs). This case report describes a 77-year-old woman with a history of invasive bladder cancer treated with pembrolizumab who developed severe bilateral ptosis, myositis, and myocarditis.
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- Histiocytic neoplasms are rare blood-related disorders due to an excess of histiocytes in various body tissues, accounting for less than 1% of soft tissue and lymph node cancers; Langerhans cell histiocytosis (LCH) is one of the notable forms.
- A 76-year-old male experienced progressive weakness in his legs and sensory loss, leading to the discovery of an intradural intramedullary nodule at the T5 level, confirmed through MRI.
- The patient underwent surgery to remove the lesion, which was diagnosed as isolated intramedullary thoracic LCH, resolving his condition.
Inherited cardiac channelopathies are major causes of sudden cardiac death (SCD) in young people. Genetic testing is focused on the identification of single-nucleotide variants (SNVs) by Next-Generation Sequencing (NGS). However, genetically elusive cases can carry copy number variants (CNVs), which need specific detection tools.
View Article and Find Full Text PDFMarine plastic pollution is a global issue affecting ecosystems and various aspects of human life. The scientific community is exploring new monitoring and containment approaches. Because in-situ sampling campaigns are time and resource demanding, there is a focus on integrating different approaches for marine litter monitoring.
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