Publications by authors named "S Genin"
Calcium signaling is a cornerstone of plant defense responses. In this opinion article we explore how pathogens exploit this pathway by targeting calcium sensors such as calmodulin (CaM) and calmodulin-like proteins (CMLs) with their secreted effectors. We illustrate different mechanisms by which effectors manipulate calcium homeostasis, cytoskeletal dynamics, metabolism, hormone biosynthesis, gene regulation, and chloroplast function to suppress plant immunity and enhance virulence.
View Article and Find Full Text PDFRalstonia pseudosolanacearum, a plant pathogen responsible for bacterial wilt in numerous plant species, exhibits paradoxical growth in the host by achieving high bacterial densities in xylem sap, an environment traditionally considered nutrient-poor. This study combined in vitro experiments and mathematical modeling to elucidate the population dynamics of R. pseudosolanacearum within plants.
View Article and Find Full Text PDFA method for performing variable-width (thawed) Gaussian wavepacket (GWP) variational dynamics on machine-learned potentials is presented. Instead of fitting the potential energy surface (PES), the anharmonic correction to the global harmonic approximation (GHA) is fitted using kernel ridge regression─this is a Δ-machine learning approach. The training set consists of energy differences between ab initio electronic energies and values given by the GHA.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how
- epigenetic inheritance
- , specifically DNA methylation, contributes to the adaptation of the plant pathogen
- Ralstonia pseudosolanacearum
- to different host plants over many generations, challenging the traditional view that adaptation is solely based on genetic mutations.
- Researchers analyzed the
- methylomes
- of evolved bacterial clones and found
- 50 differential methylated sites (DMSs)
- associated with the EpsR regulator gene, suggesting a possible connection between these epigenetic changes and adaptation.
- The study highlights that rapid epigenetic changes can facilitate quick adaptation, and certain changes in DNA methylation may persist for long periods, indicating a potential mechanism for long-term adaptation in bacterial pathogens.*
Article Synopsis
- The study explores how diverse host plants influence the genetic and phenotypic evolution of a plant pathogen, focusing on populations evolved on five different host types.
- Researchers found that while major genetic changes were limited, significant changes in gene expression (transcriptomic variations), especially in genes related to bacterial virulence, occurred in evolved clones.
- The results indicated two distinct patterns of gene deregulation based on host genotype, suggesting that the adaptation process is more tied to the type of host rather than its resistance/susceptibility to the pathogen.