Publications by authors named "S Gemma"
KDM4A-F enzymes are a subfamily of histone demethylases containing the Jumonji C domain (JmjC) using Fe(II) and 2-oxoglutarate for their catalytic function. Overexpression or deregulation of KDM4 enzymes is associated with various cancers, altering chromatin structure and causing transcriptional dysfunction. As KDM4 enzymes have been associated with malignancy, they may represent novel targets for developing innovative therapeutic tools to treat different solid and blood tumors.
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- The study investigates how the bioeffector wood distillate (WD), a plant biostimulant, affects the biochemical and nutritional profile of apples when applied weekly from May to September 2023.
- Results show that WD significantly enhances various valuable components in apples, such as phenols, flavonoids, tannins, and sugars, particularly in the pulp of the fruit.
- The findings, validated by advanced techniques like NMR and LC-ESI-MS, suggest that using WD could be beneficial for improving fruit tree cultivation.
Article Synopsis
- * Among the leukemias, acute myeloid leukemia (AML) is highly aggressive with poor survival rates, especially in patients with specific gene mutations, while hairy cell leukemia (HCL) remains rare and untreated with approved drugs.
- * New epigenetic therapies, particularly histone deacetylase (HDAC) inhibitors, show promise in targeting blood cancers, with new hydroxamic acid derivatives demonstrating effectiveness in inducing cell death and improving outcomes in models of AML and other blood cancers.
Inherited retinal diseases, which include retinitis pigmentosa, are a family of genetic disorders characterized by gradual rod-cone degeneration and vision loss, without effective pharmacological treatments. Experimental approaches aim to delay disease progression, supporting cones' survival, crucial for human vision. Histone deacetylases (HDACs) mediate the activation of epigenetic and nonepigenetic pathways that modulate cone degeneration in RP mouse models.
View Article and Find Full Text PDFFibrosis, sustained by the transformation of intestinal epithelial cells into fibroblasts (epithelial-to-mesenchymal transition, EMT), has been extensively studied in recent decades, with the molecular basis well-documented in various diseases, including inflammatory bowel diseases (IBDs). However, the factors influencing these pathways remain unclear. In recent years, the role of the gut microbiota in health and disease has garnered significant attention.
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