Publications by authors named "S Gehlert"
Article Synopsis
- Desmin intermediate filaments are important for muscle health, helping with stress management and protection; their breakdown leads to muscle damage and atrophy.
- A study was conducted on 10 healthy individuals who underwent 14 sessions of eccentric accentuated resistance exercise to see how this exercise affects desmin regulation and stability.
- Results showed that resistance exercise alters desmin phosphorylation patterns and reduces its cleavage susceptibility, suggesting that desmin adaptation plays a key role in muscle response to stress and injury over time.
Nicotinamide adenine dinucleotide (NAD) coenzymes are the central electron carriers in biological energy metabolism. Low NAD levels are proposed as a hallmark of ageing and several diseases, which has given rise to therapeutic strategies that aim to tackle these conditions by boosting NAD levels. As a lifestyle factor with preventive and therapeutic effects, exercise increases NAD levels across various tissues, but so far human trials are mostly focused on skeletal muscle.
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- COPD leads to muscle dysfunction, which may be linked to the spatial relationship between satellite cells and capillaries in muscle tissue.
- A study compared muscle biopsies from 18 COPD patients and 18 healthy older adults, assessing muscle fiber types, satellite cell numbers, and capillary proximity.
- Results showed COPD patients had more type II muscle fibers, reduced capillarisation, and greater distances between satellite cells and capillaries, potentially impacting satellite cell function in COPD.
Modulation of testing conditions such as resting lactate (La) levels or carbohydrate intake may affect the calculation of the maximal glycolytic rate (νLa.max). To evaluate the impact of elevated La as well as reduced and increased carbohydrate availability on νLa.
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