Publications by authors named "S Gavrilovic"
: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury with high mortality, characterized by hypoxemic respiratory failure and diffuse lung damage. Despite advancements in care, no definitive biomarkers have been established for ARDS diagnosis and prognostic stratification. Soluble receptor for advanced glycation end-products (sRAGE), a marker of alveolar epithelial injury, has shown promise as a prognostic indicator in ARDS.
View Article and Find Full Text PDFMitochondria play critical roles in regulating cell fate, with dysfunction correlating with the development of multiple diseases, emphasizing the need for engineered nanomedicines that cross biological barriers. Said nanomedicines often target fluctuating mitochondrial properties and/or present inefficient/insufficient cytosolic delivery (resulting in poor overall activity), while many require complex synthetic procedures involving targeting residues (hindering clinical translation). The synthesis/characterization of polypeptide-based cell penetrating diblock copolymers of poly-L-ornithine (PLO) and polyproline (PLP) (PLO-PLP, n:m ratio 1:3) are described as mitochondria-targeting nanocarriers.
View Article and Find Full Text PDFArticle Synopsis
- Nanofabrication has advanced significantly due to DNA origami, which helps create intricate nanoscale structures with potential new biological functions.
- A new method using the E.coli Min protein system allows for the rapid assembly of these DNA structures in about 30 minutes, greatly improving efficiency over older methods.
- This technique enables the creation of various patterns and complex designs, like core-shell patterns, and shows promise for future uses in fields such as plasmonics, catalysis, and molecular sensing.
Article Synopsis
- * The study focuses on how man-made light-activated rotary motors affect biological membranes, revealing significant mechanical changes, including membrane expansion when these motors are activated.
- * Key findings highlight that factors like motor concentration and membrane fluidity impact these changes, with continuous expansion observed as long as the motors are energized, providing insights for future applications in chemical biology.