Revisit to Endolymphatic Duct Identification Using Middle Cranial Fossa Dural Plate: A Novel Technique.

Objectives: Surgical treatments for Ménière's disease differ in efficacy. Endolymphatic duct blockage (EDB) is favored for its minimal risk and ability to preserve hearing. One of the main challenges in the technique is the difficulty in accurately identifying the endolymphatic duct (ED).

Optimizing Drug Delivery to the Brain for Breast Metastasis: A Novel Method for Tumor Targeting.

Introduction: Brain metastases are difficult to treat due to the blood-brain barrier limiting the delivery of therapeutic agents to the brain effectively. Intraventricular drug delivery has not been well studied for intra-axial pathologies. However, our prior work demonstrated that intraventricular drug delivery in a hyperosmolar vehicle showed preferential accumulation of drug within breast cancer tissue compared to surrounding brain parenchyma.

Revisiting the Intratemporal Course of the Facial Nerve.

Introduction The facial nerve displays a lot of variations and anomalies in its course. Having sound knowledge about the surgical anatomy along with its intricacies is essential in mastoid surgeries. In this study, we have documented the angle of deviation of the mastoid segment of the facial nerve during its intratemporal course and the importance of this angle during mastoid surgeries.

Deep learning potential of mean force between polymer grafted nanoparticles.

Grafting polymer chains on the surfaces of nanoparticles is a well-known route to control their self-assembly and distribution in a polymer matrix. A wide variety of self-assembled structures are achieved by changing the grafting patterns on the surface of an individual nanoparticle. However, an accurate estimation of the effective potential of mean force between a pair of grafted nanoparticles that determines their assembly and distribution in a polymer matrix is an outstanding challenge in nanoscience.