Publications by authors named "S Gatechompol"
Article Synopsis
- Mental health issues and substance use disorders are prevalent among people living with HIV (PLHIV) and contribute to risky sexual behaviors, especially in the Asia-Pacific region where data is scarce.
- A study involving 723 adult PLHIV revealed that a significant portion (37%) engaged in medium- to high-risk sexual practices, with such behaviors being more prevalent among younger individuals, those who are unemployed, and those experiencing moderate to severe depression or high-risk substance use.
- The findings highlight the need for integrating mental health support and substance use harm reduction within HIV care to improve sexual health outcomes in this population.
Tuberculosis is the most common opportunistic infection in individuals with HIV, and rifampicin is crucial in the treatment of tuberculosis. Drug-drug interactions complicate the use of DTG in HIV/TB co-infection, which makes drug administration more difficult. This study aimed to develop the population pharmacokinetic model of DTG when co-administered with rifampicin.
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- Non-sputum-based tests are crucial for diagnosing tuberculosis (TB) in people living with HIV (PWH), and the Kyn-to-Trp (K/T) plasma ratio may serve as a promising biomarker to predict TB disease in these patients on antiretroviral therapy (ART).
- The study measured K/T ratios at three different time points (at diagnosis, 6 months before, and 6 months after) in PWH who developed TB, revealing significantly higher ratios at diagnosis compared to matched controls.
- Following successful TB treatment, K/T ratios significantly dropped, but they increased in cases of treatment failure, suggesting the ratio could be useful for monitoring TB treatment in PWH, pending further validation studies.
Introduction: Immune dysregulation persists in people with HIV (PWH) on antiretroviral therapy (ART) and may lead to accelerated vascular ageing and cardiovascular disease (CVD). While delayed time to initiation of ART has been linked to worse cardiovascular outcomes, the effect of ART initiation during acute infection on these outcomes is not well understood.
Methods: Participants were enrolled from the SEARCH010/RV254 acute HIV (AHI) and HIV-NAT chronic HIV (CHI) cohorts in Thailand.
ChulaCov19 mRNA vaccine demonstrated promising phase 1 results. Healthy adults aged 18-59 years were double-blind randomised 4:1 to receive two intramuscular doses of ChulaCov19 50 µg or placebo. Primary endpoints were safety and microneutralization antibody against-wild-type (Micro-VNT50) at day 50.
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