Publications by authors named "S Garrigues"
Stabilization of cereblon (CRBN)/neosubstrate complexes with molecular glues followed by degradation of those neosubstrates is an emerging strategy in drug discovery with compelling potential to target certain proteins that were previously considered to be undruggable. In this context, the discovery of novel CRBN ligands is an important area of ongoing research that holds promise to expand the scope of proteins that can be targeted through this mode of action. Herein, we describe the synthesis and evaluation of CRBN ligands featuring heteroaryl glutarimide and dihydrouracil scaffolds.
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- Antifungal proteins (AFPs), particularly PeAfpA from Penicillium expansum, exhibit strong antifungal activity, though their mechanisms remain unclear.
- PeAfpA influences the morphology and growth of P. digitatum without causing a spike in reactive oxygen species like the less effective PdAfpB.
- Live-cell imaging showed PeAfpA's dynamic interaction with various P. digitatum states, leading to its eventual internalization in hyphae and triggering cell death, providing insights for future biofungicide development.
Filamentous Fungi as Excellent Industrial Strains: Development and Applications.
J Fungi (Basel)
August 2024
Europe is transitioning towards a biologically based economy to reduce harmful and greenhouse emissions, promoting more sustainable industrial practices [...
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- The study explores how intense exercise impacts metabolic changes and urine composition, suggesting these insights can enhance training and recovery approaches.
- The researchers used non-invasive ATR-FTIR spectroscopy and multivariate analysis to monitor urine from 21 volunteers, with significant changes noticed after a 10 km run, especially peaking at 11 hours post-exercise.
- The findings highlight that this method effectively detects metabolic variations in urine, making it a promising tool for evaluating recovery strategies in athletes.
Background: Penicillium digitatum is a fungal plant pathogen that causes the green mold disease in harvested citrus fruits. Due to its economical relevance, many efforts have focused on the development of genetic engineering tools for this fungus. Adaptation of the CRISPR/Cas9 technology was previously accomplished with self-replicative AMA1-based plasmids for marker-free gene editing, but the resulting efficiency (10%) limited its practical implementation.
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