[Thoughts about screening for Down syndrome].

The more important clinical manifestations and the opportunities of screening for Down syndrome are briefly summarized in this paper. The methods used for screening (biochemical markers, fetal ultrasound signs) and the most important screening tests (combined screening, integrated screening) are described. Then, the author analyses the situation of screening in Hungary, and he emphasizes that maternal age over 35 years, and low serum level of alpha-fetoprotein cannot be the only indication for amniocentesis.

[Clinical significance of subchorionic and retroplacental hematomas detected in the first trimester of pregnancy].

Aims: To evaluate the long-term clinical significance of intrauterine hematomas detected in the first trimester of pregnancy in a general obstetric population.

Methods: A prospective study was designed to compare the perinatal outcome in 187 pregnant women with intrauterine hematomas to 6488 controls in which hematomas were not detected at first trimester by ultrasound examination.

Results: The incidence of intrauterine hematoma in the first trimester in a general obstetric population was 3.

Clinical significance of subchorionic and retroplacental hematomas detected in the first trimester of pregnancy.

Objective: To evaluate the long-term clinical significance of intrauterine hematomas detected in the first trimester of pregnancy in a general obstetric population.

Methods: A prospective study was designed to compare perinatal outcomes in 187 pregnant women with intrauterine hematomas and 6488 controls in whom hematomas were not detected at first-trimester ultrasonographic examination.

Results: The incidence of intrauterine hematoma in the first trimester in a general obstetric population was 3.

[Ursodeoxycholic acid treatment in intrahepatic cholestasis of pregnancy. A case report].

Introduction: Intrahepatic cholestasis of pregnancy is a rare disorder of unknown origin with a symptomatically distressing maternal course with pruritus and icterus as the chief complaints. The disease poses little medical risk to the mother, but poses significantly risk to the fetus of perinatal mortality, preterm delivery, fetal distress, and meconium staining. Beside the pruritus and the high level of bilirubin in the serum the increased values of parameters showing the liver function and of alkaline phosphatase activity are characteristic.