Publications by authors named "S Gantz"

Article Synopsis
  • Proton Minibeam Radiation Therapy has been promising in enhancing treatment efficacy compared to traditional radiation, but more research into its biological mechanisms is needed.
  • A mechanical collimation setup was developed to produce 250µm minibeams with a 1000µm spacing, with optimization using Monte Carlo simulations conducted at various proton therapy sites.
  • Results showed a peak-to-valley dose ratio (PVDR) of 10 in Dresden and 14 in Seattle, with some discrepancies between dosimetry methods that can be addressed with correction factors.
View Article and Find Full Text PDF

Background: The number of patients who have experienced violence is increasing worldwide. These patients have specific psychosocial and forensic needs and can present unique challenges to the health care workers caring for them.

Objective: To identify best practices for the care of patients with injuries from violence in the emergency department or inpatient setting.

View Article and Find Full Text PDF

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes.

View Article and Find Full Text PDF

Theevolution of radiotherapy necessitates innovative platforms for preclinical investigation, bridging the gap between bench research and clinical applications. Understanding the nuances of radiation response, specifically tailored to proton and photon therapies, is critical for optimizing treatment outcomes. Within this context, preclinicalexperimental setups incorporating image guidance for both photon and proton therapies are pivotal, enabling the translation of findings from small animal models to clinical settings.

View Article and Find Full Text PDF
Article Synopsis
  • Noradrenaline transmission in the brain is key for regulating wakefulness and attention, and abnormalities in this system can lead to disorders related to hyper- and hypo-arousal.
  • Aberrant transmission often interacts with serotonin, as noradrenaline influences serotonin neuron activity through excitatory receptors.
  • Research using brain slice preparation showed that activation of specific noradrenergic inputs can excite serotonin neurons, while inhibitory receptors can dampen this activity, highlighting the complex regulation of serotonin neuron excitability by noradrenergic systems.
View Article and Find Full Text PDF