Synthesis, characterization and antibacterial study of Ag-Au Bi-metallic nanocomposite by bioreduction using piper betle leaf extract.

Biological reduction method using plant extract for the synthesis of metal and metal oxides are attracted much to the researchers due to its simplicity, which integrates the chemical technology. The special attention is given to the green synthesis of nanoparticles by easily available plants with eco-friendly system compared to other conventional methods. Silver-gold nanocomposite (Ag-Au NCp's) is synthesized by biological reduction of silver nitrate and gold chloride with biological reduction method.

Synthesis, characterization and antibacterial study of Ag doped magnesium ferrite nanocomposite.

Nanomaterials are attracted a great deal of attention from scientific community due its unique properties and applications. The small size ferrites have opened up the door for intensive research to utilize their properties for biomedical applications. Ferrite nanomaterials like MgFeO and its silver doped nanocomposites (Ag- MgFeO) have been prepared using solid state combustion method using polyvinyl alcohol (PVA) as a fuel.

Reproductive toxicology studies supporting the safety of molindone, a dopamine receptor antagonist.

Background: An extended-release molindone (a dopamine D and serotonin antagonist) is currently being developed as a novel treatment for impulsive aggression (IA) in patients optimally treated for ADHD. Oral Good Laboratory Practice reproductive toxicology studies (fertility and early embryonic [FEE], prenatal/postnatal [PPN], embryo-fetal development [EFD]) were conducted with molindone HCl using International Conference on Harmonisation (ICH) S5(R2)-compliant protocols.

Methods: In the FEE study, 0, 5, 15, or 30 mg kg  day was administered to female (2 weeks premating through implantation) and male (4 weeks premating for 57 days) rats, and fertility parameters were evaluated.

Reversibility of dopamine receptor antagonist-induced hyperprolactinemia and associated histological changes in Tg RasH2 wild-type mice.

The purpose of this study was to better understand the biological effects of increased prolactin levels induced in mice by dopamine D2 receptor antagonist molindone treatment. Toxicokinetics, prolactin levels, and reproductive tissue histology were evaluated in Tg rasH2 wild-type mice treated orally with molindone at 0, 5, 15, and 50mg/kg/day for 6 months, followed by a 2-month posttreatment recovery period. A greater than dose-proportional increase in molindone exposure ([AUC]0‒24) was observed on Day 180 for both sexes.