Publications by authors named "S Gadd"
Diffuse midline glioma (DMG) H3K27-altered is one of the most malignant childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%. Several clinical trials have attempted to enhance radiation antitumor activity using radiosensitizing agents, although none have been successful.
View Article and Find Full Text PDFArticle Synopsis
- - The study of Wilms tumour, which began with Alfred Knudson's 'two-hit' model, has advanced significantly over the last 50 years, leading to important discoveries in its genetics and biology.
- - Research has focused on identifying prognostic biomarkers to improve treatment outcomes, although variability in these biomarkers within tumors creates challenges for individual patient care.
- - Despite progress, ongoing investigations aim to deepen molecular understanding of Wilms tumour, including causes of relapse and bilateral cases, with international collaboration being key to addressing these complex issues.
Unlabelled: Long noncoding RNAs (lncRNA) play an important role in gene regulation and contribute to tumorigenesis. While pan-cancer studies of lncRNA expression have been performed for adult malignancies, the lncRNA landscape across pediatric cancers remains largely uncharted. Here, we curated RNA sequencing data for 1,044 pediatric leukemia and extracranial solid tumors and integrated paired tumor whole genome sequencing and epigenetic data in relevant cell line models to explore lncRNA expression, regulation, and association with cancer.
View Article and Find Full Text PDFAssessing the impact of a leadership and advocacy elective course in a college of pharmacy curriculum.
Curr Pharm Teach Learn
September 2023
Introduction And Leadership Framework: While the scope of a pharmacist's work has grown, continued advocacy is needed to ensure that their skillset is used to the best advantage of the patient. To accomplish this aim, the University of Utah College of Pharmacy created an elective advocacy and leadership class to train students in leadership and advocacy methods, with a focus on enabling students to practice advocacy within the state of Utah throughout the class.
Educational Context And Methods: In addition to traditional lectures, this class asked students to apply the knowledge learned in class to projects within their sphere of influence.