Publications by authors named "S GARATTINI"
Article Synopsis
- Paclitaxel plus ramucirumab is being evaluated as a second-line treatment for patients with advanced HER2-negative gastric or gastro-oesophageal junction cancer, comparing it with continued oxaliplatin and fluoropyrimidine chemotherapy.
- The ARMANI trial involved 280 patients, who were randomly assigned to receive either the new treatment regimen or continue with their current chemotherapy for an additional 12 weeks.
- The primary goal of the study was to determine if the new treatment improved progression-free survival compared to the standard chemotherapy, with safety being closely monitored throughout the trial.
[NNT and NNH: statistics and stochastics in the evaluation of added therapeutic value].
G Ital Cardiol (Rome)
November 2024
Any pharmacological, invasive, surgical health intervention should have an added therapeutic value as well as the requirements of quality, safety, efficacy, to be considered as a medical device based on scientific evidence and of clinical utility for the patient. The intervention should be shared between the doctor and the patient who should have rigorous but simple tools to decide on the best therapy to undertake. Assessment of relative risk reduction is commonly used in the scientific literature to quantify both statistical and clinical significance.
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- Gastric cancer is a type of stomach cancer that is really complicated and has low survival rates, but researchers are studying a vitamin-A related substance called retinoic acid to help treat it.
- The study looked at samples from 55 patients to see how certain genes are expressed in their tumors and if these could help predict how the cancer is progressing.
- Results showed that some gene levels were higher in patients with more serious cancer stages, which could mean that these genes might help doctors understand and treat gastric cancer better in the future.
Unlabelled: Guidelines advocate that the symptomatic management of fever should prioritize alleviating the child's discomfort. We investigated the definition and assessment of discomfort in febrile children within the scientific pediatric literature. A systematic review was conducted in accordance with PRISMA 2020 guidelines and preregistered on the Prospero database (CRD42023471590).
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