Publications by authors named "S G Yoder"
Several therapeutic agents have been approved for treating multiple myeloma (MM), a cancer of bone marrow resident plasma cells. Predictive biomarkers for drug response could help guide clinical strategies to optimize outcomes. Here, we present an integrated functional genomic analysis of tumor samples from MM patients that were assessed for their ex vivo drug sensitivity to 37 drugs, clinical variables, cytogenetics, mutational profiles, and transcriptomes.
View Article and Find Full Text PDFArticle Synopsis
- Lineage plasticity in cancer affects treatment effectiveness, and this study presents a new in vivo method to explore neuroendocrine lineage changes in prostate cancer progression.* -
- Researchers found that mouse prostate organoids with specific mutations form aggressive neuroendocrine prostate cancer (NEPC) when Rb1 is deleted, but only in the right in vivo environment, unlike traditional organoid cultures.* -
- The study shows that ASCL1 cells originate from KRT8 luminal cells and that losing Ascl1 in NEPC leads to temporary regression but later recurrence; however, deleting it before transplantation prevents lineage changes and results in more treatable adenocarcinomas.*
Background: The radiation sensitivity index (RSI) and 12-chemokine gene expression signature (12CK GES) are two gene expression signatures (GES) that were previously developed to predict tumor radiation sensitivity or identify the presence of tertiary lymphoid structures in tumors, respectively. To advance the use of these GES into clinical trial evaluation, their assays must be assessed within the context of the Clinical Laboratory Improvement Amendments (CLIA) process.
Methods: Using HG-U133Plus 2.
Cellular and molecular characterization of immune responses elicited by influenza virus infection and seasonal vaccination have informed efforts to improve vaccine efficacy, breadth, and longevity. Here, we use negative stain electron microscopy polyclonal epitope mapping (nsEMPEM) to structurally characterize the humoral IgG antibody responses to hemagglutinin (HA) from human patients vaccinated with a seasonal quadrivalent flu vaccine or infected with influenza A viruses. Our data show that both vaccinated and infected patients had humoral IgGs targeting highly conserved regions on both H1 and H3 subtype HAs, including the stem and anchor, which are targets for universal influenza vaccine design.
View Article and Find Full Text PDF