[Evaluation of the antiviral therapy for chronic hepatitis C in patients unresponsive to previous treatment with regard to the interleukin-28B genotypes].

The identification of the single nucleotide polymorphisms (SNP) at rs8099917 and rs12979860 loci of IL-28B gene is presently necessary for patients with the genotype HCV-1 to predict sustained viral response (SVR) in case of combined antiviral therapy with interferon and ribavirin. In addition to the implementation of the antiviral activity of IFN-α, interleukin-1β (IL-1β) and interferon-gamma (IFN-γ) are involved. The goal of this work was to evaluate the efficacy of the HCV therapy with cytokines in patients unresponsive to previous therapy with unfavorable genotypes of IL-28B gene.

[Applying of recombinant interleukin-1β to treat chronic hepatitis C for patients non-response to the previous antiviral therapy].

Unlabelled: The search for rational treatment of CHC patients, non-response to the primary antiviral therapy especially with unfavorable genotypes for interleukin-28B, remains valid.

Purpose: To evaluate the efficacy and safety of recombinant IL-1β (Betaleukin) in combined antiviral therapy in patients with chronic hepatitis C who did not respond to previous treatment. The study included 26 patients with HCV-1.

[Pegylated intereferon hematological safety in comparison with standard].

Comparative analysis of adverse hematologic effects in 135 patients with with chronic hepatits C on combined antiviral therapy of pegylated and "short lived" forms of alpha-interferon in combination with ribavirin was investigated. As a result of the comparison, the response to antiviral therapy in patients with chronic hepatitis C treated with daily administration of simple interferon-alpha in hematologic data is similar in patients undergoing treatment with pegylated drugs.

[Efficacy of low intensity laser irradiation and sodium nedocromil in the complex treatment of patients with bronchial asthma].

Aim: To study efficiency of low-intensity laser radiation (LILR) and sodium nedokromil (tailed) in combined treatment of bronchial asthma (BA).

Material And Methods: The choice of the treatment depended on the activity of bronchial inflammation and the presence of contraindications. Laser was used on the skin in the area of the lung and great vessels projection, endobronchially.

[Intestinal microflora and concomitant gastrointestinal diseases in patients with chronic hepatitis B and C].

In chronic viral hepatitis B and C the development of intestinal dysbacteriosis and high occurrence of concomitant diseases of the gastrointestinal tract were observed. In cases of increased dysbacteriosis degree and in the presence of concomitant diseases the blood plasma of patients exhibited higher activity in reaction with the of amebocytes lysate obtained from crabs of the genus Limulus. A suggestion was made that the endotoxin of Gram negative intestinal microflora could probably play some role in the development of pathological processes in chronic viral hepatitis B and C.