Theranostic Applications of an Ultra-Sensitive and Magnetic Resonance Contrast Agent Based on Cobalt Ferrite Spinel Nanoparticles.

Nano-dimensional materials have become a focus of multiple clinical applications due to their unique physicochemical properties. Magnetic nanoparticles represent an important class of nanomaterials that are widely studied for use as magnetic resonance (MR) contrast and drug delivery agents, especially as they can be detected and manipulated remotely. Using magnetic cobalt ferrite spinel (MCFS) nanoparticles, this study was aimed at developing a multifunctional drug delivery platform with MRI capability for use in cancer treatment.

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials.

The increasing growth in the development of various novel nanomaterials and their biomedical applications has drawn increasing attention to their biological safety and potential health impact. The most commonly used methods for nanomaterial toxicity assessment are based on laboratory experiments. In recent years, with the aid of computer modeling and data science, several in silico methods for the cytotoxicity prediction of nanomaterials have been developed.

Role of Adhesion Stress in Controlling Transition between Plastic, Grinding and Breakaway Regimes of Adhesive Wear.

A discrete-element based model of elastic-plastic materials with non-ideal plasticity and with an account of both cohesive and adhesive interactions inside the material is developed and verified. Based on this model, a detailed study of factors controlling the modes of adhesive wear is performed. Depending on the material and loading parameters, we observed three main modes of wear: slipping, plastic grinding, cleavage, and breakaway.

Biodegradable nanocomposite Fe-Ag load-bearing scaffolds for bone healing.

Processing and properties of biodegradable load-bearing nanocomposite Fe-Ag scaffolds for bone ingrowth are reported. Fe-Ag nanocomposites were prepared employing high energy attrition milling of powders. Scaffolds with regular interconnected 300-400 μm pores and 60-75% porosity were prepared by cold sintering/high pressure consolidation of nanocomposite Fe-Ag granules, blended with porogen - highly water soluble sugar particles.

Effect of elastic grading on fretting wear.

We consider fretting wear in elastic frictional contact under influence of oscillations of small amplitude and investigate the question, how wear damage can be influenced by the introduction of material gradients. To achieve a general understanding we restrict our consideration to media with a power-law dependency of the elastic modulus on depth. In this case, a complete analytical solution can be found for the final worn shape.