Publications by authors named "S G Pauker"

Article Synopsis
  • The study investigates balanced chromosomal abnormalities (BCAs) in 273 individuals with congenital anomalies using whole-genome sequencing to achieve higher resolution than traditional karyotyping.
  • The findings revealed that 93% of karyotypes were revised, with 21% of BCAs showing complexity not detectable by standard methods, highlighting the limitations of cytogenetics.
  • The research indicated that 33.9% of BCAs caused gene disruption tied to developmental issues, and some breakpoints affected crucial genomic regions, possibly worsening conditions like 5q14.3 microdeletion syndrome due to altered gene expression.
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Purpose: Magnetic resonance imaging (MRI) is a high-cost imaging modality, and an optimized encounter ideally provides high-quality care, patient satisfaction, and capacity utilization. Our purpose was to assess the effectiveness of team training and its impact on patient show-up and completion rates for their MRI examinations.

Materials And Methods: A total of 97,712 patient visits from three tertiary academic medical centers over 1-year intervals were evaluated, totaling 49,733 visits at baseline and 47,979 after training.

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Background: There are no randomized controlled trials to inform the decision of which cranial radiation therapy (CRT) strategy to apply to pediatric patients with T-cell acute lymphoblastic leukemia (ALL).

Procedure: We performed a decision analysis using a Markov model in which we compared the life expectancy and quality-adjusted life expectancy when administering one of three CRT strategies to a cohort of patients with T-cell ALL: (1) omission of CRT for all patients; (2) CRT only for those with evidence of leukemic involvement in the central nervous system at diagnosis (therapeutic strategy); or (3) CRT for all (prophylactic strategy).

Results: When considering plausible event-free survival rates and late mortality after cure for groups of pediatric patients with T-cell ALL, the strategies of omitting CRT, administering therapeutic CRT, and administering prophylactic CRT result in similar short-term (7-year) survival.

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Background: The threshold model represents an important advance in the field of medical decision-making. It is a linchpin between evidence (which exists on the continuum of credibility) and decision-making (which is a categorical exercise - we decide to act or not act). The threshold concept is closely related to the question of rational decision-making.

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