Utility of Community-Based Gait Speed Outcome Measures and Cut-Offs for Stroke.

Purpose: Chronic stroke is associated with declines in gait speed (GS) associated with loss of participation, endurance, and increased institutionalization. GS categories described by Perry and Fulk can designate gait function and set goals for rehabilitation. It is unknown which GS tests and associated functional categories have better utility for goal setting in a group of community-dwelling patients with chronic stroke.

Quantitative Assessment of Pulmonary Fibrosis in a Murine Model via a Multimodal Imaging Workflow.

Disease-recapitulating animal models are valuable tools in preclinical development for the study of compounds. In the case of fibrotic pulmonary diseases such as idiopathic pulmonary fibrosis (IPF), the bleomycin model of lung injury in the mouse is widely used. To evaluate bleomycin-induced changes in the lung, we employed a quantitative, multimodal approach.

Influenza and COVID-19 vaccination in Canadian blood donors: A comparison across pre- and post-pandemic periods.

Background And Objectives: Seasonal vaccinations reduce donor illness and appointment cancellations and ensure plasma products have antibodies to vaccine-directed strains. We aimed to describe donor influenza and COVID-19 vaccination history and compare this with the general population.

Materials And Methods: Two online donor surveys were carried out in 2021 and 2024.

A Bayesian Re-analysis of the Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) Trial.

Background: Prophylactic steroids are often used to reduce the systemic inflammatory response to cardiopulmonary bypass in infants undergoing heart surgery. The STRESS trial found that the likelihood of a worse outcome did not differ between infants randomized to methylprednisolone (n=599) versus placebo (n=601) in a risk-adjusted primary analysis (adjusted odds ratio [OR], 0.86; 95% CI, 0.