Publications by authors named "S G NICOLAU"
Article Synopsis
- - This study introduces a new type of autoimmune myopathy called immune-mediated megaconial myopathy (IMMM), which is recognized by the presence of giant mitochondria in muscle tissue.
- - Researchers analyzed data from the Mayo Clinic to identify five patients with cases of IMMM, who displayed symptoms like progressive muscle weakness, high creatine kinase levels, and specific muscle fiber characteristics.
- - Treatment with immunomodulatory therapy showed improvements in most patients, and interestingly, all of them had simultaneous pancreatic diseases, suggesting a possible link that requires further investigation.
Background: Bacterial persistence is a phenomenon whereby a subpopulation of bacteria survive high concentrations of an active antibiotic in the absence of phenotypic alterations. Persisters are associated with chronic and recurrent infections for pathogens including Pseudomonas aeruginosa. Understanding persister profiles of newer antibiotics such as cefiderocol and ceftolozane/tazobactam against P.
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- Neurogenetic disorders linked to mutations in spectrin genes lead to a wide range of symptoms, from peripheral nervous system issues to complex syndromes, emphasizing their diverse impact.
- An international study identified 14 families with unexplained distal weakness due to heterozygous loss-of-function variants, collecting standardized clinical and imaging data to analyze the condition further.
- The research found that all 20 patients exhibited early childhood onset of distal weakness with varying severity, along with associated foot abnormalities and muscle changes, confirming the link between these genetic variants and a new syndrome characterized by primarily myogenic effects.
Chagas disease is a parasitic disease caused by the protozoan Trypanosoma cruzi with an acute, detectable blood parasites phase and a chronic phase, in which the parasitemia is not observable, but cardiac and gastrointestinal consequences are possible. Mice are the principal host used in experimental Chagas disease but reproduce the human infection depending on the animal and parasite strain, besides dose and route of administration. Lipidic mediators are tremendously involved in the pathogenesis of T.
View Article and Find Full Text PDFAn evaluation of resolution, accuracy, and precision in FT-IR spectroscopy.
Spectrochim Acta A Mol Biomol Spectrosc
October 2024
Infrared spectroscopy is a foundational technique for the elucidation of chemical structures. The advancements in interferometric spectroscopy, and specifically the development of Fourier transform infrared (FT-IR) spectroscopy, are responsible for the widespread usage of IR spectrometers ranging from teaching labs to pharmaceutical quality control. FT-IR affords an excellent signal-to-noise ratio that permits sensitive sampling with quantitative accuracy and high wavenumber precision based on well documented advantages (Jacquinot, Fellgett, Connes).
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