Publications by authors named "S G Moeller"
Purpose: To develop and characterize the performance of a 128-channel head array for brain imaging at 10.5 tesla and evaluate the potential of brain imaging at this unique, >10 tesla magnetic field.
Methods: The coil is composed of a 16-channel self-decoupled loop transmit/receive array with a 112-loop receive-only (Rx) insert.
NOise Reduction with DIstribution Corrected (NORDIC) principal component analysis improves brain activity detection across rodent and human functional MRI contexts.
Imaging Neurosci (Camb)
October 2024
NOise Reduction with DIstribution Corrected (NORDIC) principal component analysis (PCA) has been shown to selectively suppress thermal noise and improve the temporal signal-to-noise ratio (tSNR) in human functional magnetic resonance imaging (fMRI). However, the feasibility to improve data quality for rodent fMRI using NORDIC PCA remains uncertain. NORDIC PCA may also be particularly beneficial for improving topological brain mapping, as conventional mapping requires precise spatiotemporal signals from large datasets (ideally ~1 hour acquisition) for individual representations.
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- The study aims to enhance ultrahigh-field brain imaging by evaluating the achievable signal-to-noise ratio (SNR) against the ultimate intrinsic SNR (uiSNR) at 10.5T, and exploring designs to improve SNR for better imaging results.
- A specialized 16-channel Tx/Rx array and a 64-channel receive-only array were created for use with the 10.5T MRI, with experiments confirming safe operational limits and comparisons of SNR at 10.5T and 7T.
- Results indicated that the technology can capture significant portions of uiSNR at 10.5T for high-resolution imaging, demonstrating its effectiveness for functional MRI, setting the stage for future advanced studies of the human
Article Synopsis
- The study investigates the relationship between midbrain dopamine function and substance use frequency and severity in young adults aged 20-24, particularly focusing on women.
- Researchers used neuromelanin-sensitive MRI (NM-MRI) to measure lifetime dopamine function in the substantia nigra/ventral tegmentum area (SN-VTA) among 135 participants.
- Results indicate that higher cumulative substance use correlates with increased NM-MRI signal in the SN-VTA, suggesting altered dopamine function is associated with substance use history, but not with individual reward function traits.
We report the measurement of impulsive stimulated x-ray Raman scattering in neutral liquid water. An attosecond pulse drives the excitations of an electronic wavepacket in water molecules. The process comprises two steps: a transition to core-excited states near the oxygen atoms accompanied by transition to valence-excited states.
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