[Main concepts of preventive health care for the air staff of sea-based aviation].

The authors researched the air-stuff and complex of adverse factors uncharacteristic for the air-staff of land-based aircraft. It was determined that adverse factors affect the air-staff foremost in 4-5 months of a blue-water sailing, except cardiovascular system diseases. In a month of a blue-water sailing was registered a hypotonic state.

[Psychophysiological aspects of naval aviation pilots of the Navy in the operation of highly carrier-based aircraft].

The authors have shown that the most difficult elements of the flight deck of the ship are springboard takeoff and aerofinishing landing. An important task is to study the aerodynamic characteristics of the behavior of the aircraft during takeoff different characteristics, forming crews ready to act in particular situations. Adverse factors are the operating conditions of habitability of aircraft (noise, vibration, fumes in the air at work, and aircraft engines, etc.

[About spatial orientation of flying staff in air].

Were learned peculiarities of spatial orientation by altitude of pilots and students in conditions of flying over a sea and on link trainer Yak-40, were educed psychophysiological and psychological mechanisms of perception of altitude. Was effectuated a valuation of existing and possible methods of teaching of effective orientation in air. Was shown, that pilots with different professional rate make faults as well in visual flying as visual detecting of the altitude.

Novel antitumor L-arabinose derivative of indolocarbazole with high affinity to DNA.

Novel indolocarbazole derivative 12-(alpha-L-arabinopyranosyl)indolo[2,3-alpha]pyrrolo[3,4-c]carbazole-5,7-dione (AIC) demonstrated high potency (at submicromolar concentrations) against the NCI panel of human tumor cell lines and transplanted tumors in vivo. In search of tentative targets for AIC, we found that the drug formed high affinity intercalative complexes with d(AT)(20), d(GC)(20) and calf thymus DNA (binding constants (1.6x10(6)) M(-1)< or =K(a)< or =(3.