[Prognostic factors in the surgical treatment of lung cancer].

Some prognostic signs of surgical treatment of carcinoma of the lung are analysed. The stability and paramount importance of the integral clinical factor "extension of the tumor" is shown. The ultrastructural features of adenocarcinoma and squamous-cell carcinoma of the lungs influencing the disease prognosis were revealed.

High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.

To evaluate the possible use of mutant ras as a biomarker for lung cancer, we have analyzed "normal appearing" lung tissue, lung tumor, lung metastases and sputum samples from patients with non-small cell lung cancer (NSCLC). As a control, we used lung tissue and sputum samples from patients without oncological diseases or lung disorders. Our analyses were performed with the aid of enriched PCR (EPCR), a method which enables detection of ras mutation even if present at low incidence.

[Large cell carcinoma of the lung: ultrastructural classification, diagnosis, prognosis].

16 lung large cell carcinomas (13 of them were followed for a long time) were studied. It is established that these tumours are a heterogeneous group of neoplasms which may be undifferentiated or with squamous, glandular, oncocytic and endocrine differentiation. Ultrastructural classification is presented reflecting diagnostic and prognostic aspects of these tumours.

Surgery for elderly patients with cancer of the cardia.

During the past 22 years, the operability rate has been 62.2% for patients 60 years or older, with cancer of the cardia (319/475). The resectability rate has been 66.

[Ultrastructure of pulmonary squamous cell carcinoma as a prognostic factor in surgical treatment].

163 operated on patients were divided into 2 groups: the 1st group--those surviving 5 years without recurrence (44.2%) and the 2nd group--those dying earlier from the tumour progression (55.8%).