[Ultrastructure of epidermocytes in true pemphigus acantholysis].

Objective: To investigate the ultrastructure of epidermocytes in skin biopsy specimens, by taking into account an update on the pathomorphogenesis of true pemphigus acantholysis.

Material And Methods: Affected skin biopsy specimens from 4 patients with Pemphigus vulgaris (a mixed mucosal-epidermal variant) and from 1 patient with P. foliaceus at the onset of the disease in the absence of therapy were examined by light microscopy of semifine sections and by transmission electron microscopy.

[Inherited epidermolysis bullosa].

To summarize an update on epidermolysis bullosa as a polymorphic group of inherited diseases with a failure of epidermal-dermal integrity. Emphasis is placed on the role of transmission electron microscopy in diagnosis and search directions for new types of the abnormality and its molecular markers. Despite numerous mutations in the genes encoding the components of desmosomes and epithelial basement membrane, the stereotyped manifestations of pathological processes in the group of epidermolysis bullosa have been identified.

[Clinical features of «metabolism» diseases of the skin in patients with chronic diffuse liver diseases].

Aim: To determine the clinical features of skin diseases developing in the presence of metabolic disturbances in patients with chronic diffuse liver diseases.

Subjects And Methods: A total of 368 patients with different clinical forms of hepatopathy were comprehensively examined.

Results: 817 cases of seborrhea, skin itch, xerodermia, xanthomatosis, and dyschromia were detected in 318 (86.

[The clinical effectiveness of the application of interferential currents for the combined treatment of onychopathies associated with psoriasis and eczema].

The frequency of the development of clinically significant changes in the nail plates was estimated in the present study that included 454 patients presenting with psoriasis and 140 patients with eczema characterized by the localization of the pathological process on the skin of the wrists and/or feet. The changes in the nail plates were shown to occur in 56,2% of the patients with psoriasis and in 90,7% of those suffering from eczema. The capillaroscopy of the microvessels feeding the affected nails was carried out to determine the type of the capillaroscopic picture.

DIAGNOSTIC SIGNIFICANCE OF SKIN "SIGNS" IN CHRONIC DIFFUSE LIVER DISFASES.

Aim: Frequency Estimation of registration of various skin changes in patients with chronic diffuse liver diseases (CDDL).

Subjects And Methods: A cross-sectional observational study in patients with CDDL and dermatological changes. The basis of this study - the results of clinical and laboratory findings 468 patients with various liver diseases (viral, toxic, parasitic).