[The characteristics of proteinuria during intensive physical loading].

Intensive physical exercise result in certain changes in the body, kidneys in particular. A total of 23 highly qualified sportsmen were investigated for plasma proteins in the urine before and after the graded bicycle ergometry. The impairment of renal reabsorption due to physical load was evidenced by significant amounts of albumin in the afterload urinalyses of all the examinees, and the appearance of IgG in urinalysis of 6 sportsmen in comparison to the urinalysis before the exercise which reported insignificant levels of albumin in 6 subjects only.

[Hepatocyte size in rats with alimentary obesity].

A comparative study was carried out on populations of the hepatic cells, taken from rats with alimentary obesity and hyperinsulinism and from animals with the normal body weight. It was concluded that the hepatic cell sizes remained unchanged in the obesity degree examined despite the morphological signs of hepatocyte changes due to accumulation of excessive cytoplasmatic lipids.

[Insulin-receptor interaction on liver cell membranes and isolated adipocytes of rats in experimental obesity].

It was established that alimentary obesity in rats was accompanied by a considerable elevation of the blood insulin level. Under these conditions the number of receptors to insulin on the rat liver cell plasmatic membranes decreased 1 1/2 to 2 times depending on the obesity degree. The receptor affinity to the hormone remained unchanged.

[Insulin-receptor interaction of plasma membranes of liver cells and isolated adipocytes of the rat with different insulin content in the blood].

Study on the insulin--receptor interaction of the plasma membranes of liver cells demonstrated a reverse dependence of insulin concentration in the blood and the number of insulin-binding sites on the membranes. Using isolated adipocytes, it was shown that at a constant number of receptors the receptor density is changed. These changes are correlated with the decrease of biological effects in experimental obesity accompanied by hyperinsulinism.

[Biological method of blood plasma glucagon determination].

Biological method of glucagon determination in the blood plasma was worked out. The method consists in incubation of the rat liver membranes with glucagon which stimulates adenylcyclase, whose activity was determined by the accretion of cAMP content in the incubation medium. Membranes with increased sensitivity of glucagon were obtained; hormone concentrations in the plasma of healthy persons and of patients suffering from diabetes were determined.