Publications by authors named "S G Larsson"
Candidate Genetic Loci Modifying the Colorectal Cancer Risk Caused by Lifestyle Risk Factors.
Clin Transl Gastroenterol
November 2024
Introduction: 65%-70% of colorectal cancer (CRC) cases are considered sporadic; they arise under the influence of environmental factors in individuals lacking a family history of CRC. Low-risk genetic variants are believed to contribute to CRC risk, in tandem with lifestyle factors.
Methods: Six hundred sixteen nonfamilial Swedish CRC cases with at least 1 of the following 5 risk factors: smoking, excessive alcohol consumption, physical inactivity, adherence to an unhealthy diet, and excess body weight were included in this study.
Article Synopsis
- Venous thromboembolism (VTE) is a common but preventable condition that can lead to fatal outcomes, such as pulmonary embolism, especially in cases of out-of-hospital cardiac arrest (OHCA).
- A study analyzing data from Sweden between 2008-2018 found that VTE was associated with OHCA in 2.0% of individuals, with a median age of 69 and a notable higher prevalence in women, particularly younger women.
- The research highlighted that those with VTE-associated OHCA had a significantly lower 30-day survival rate (2.0%) compared to the overall OHCA population (12%), indicating a need for improved awareness and prevention strategies, especially for women.
Article Synopsis
- The study aimed to uncover the molecular pathways linking type 2 diabetes (T2D) with gastrointestinal (GI) diseases using a two-stage Mendelian randomisation approach.
- Researchers utilized genetic data to evaluate the associations between T2D and various proteins, finding significant links between specific proteins and GI diseases such as cholelithiasis and cirrhosis.
- The findings highlight that certain proteins, particularly SULT2A1 and ADH1B, may mediate the relationship between T2D and GI diseases, offering new biological insights into these conditions.
Objectives: To develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis.
Methods: Synovial Fluid To detect molecular Endotypes by Unbiased Proteomics in Osteoarthritis (STEpUP OA) is an international consortium utilising clinical data (capturing pain, radiographic severity and demographic features) and knee synovial fluid from 17 participating cohorts. 1746 samples from 1650 individuals comprising OA, joint injury, healthy and inflammatory arthritis controls, divided into discovery (n = 1045) and replication (n = 701) datasets, were analysed by SomaScan Discovery Plex V4.
Background: The effect of milk on the risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) is unclear. We aimed to examine the association between non-fermented and fermented milk consumption on these endpoints and investigate the relationship between milk intake and cardiometabolic-related proteins in plasma.
Methods: Our study is based on two Swedish prospective cohort studies that included 59,998 women and 40,777 men without IHD or cancer at baseline who provided repeated measures of diet and lifestyle factors and plasma proteomics data in two subcohorts.