Probing the Histamine H Receptor Binding Site to Explore Ligand Binding Kinetics.

Analysis of structure-kinetic relationships (SKR) can contribute to an improved understanding of receptor-ligand interactions. Here, fragment (4-(2-benzylphenoxy)-1-methylpiperidine) was used in different fragment growing approaches to mimic the putative binding mode of the long residence time (RT) ligands olopatadine, acrivastine, and levocetirizine at the histamine H receptor (HR). SKR analyses reveal that introduction of a carboxylic acid moiety can increase RT at HR up to 11-fold.

[Community Nursing for people with a migration biography: a qualitative study].

Community Nursing for people with a migration biography: a qualitative study People with a migration background or with special socio-cultural needs have difficult access to health services or are affected by overuse, underuse or misuse. Community Nursing (CN), which was implemented in March 2022 in a district in Austria, can strengthen health literacy and promote individual well-being. The aim was to obtain information about perception and use of CN services by people with a migration biography and to identify adequate measures to promote increased use.

Enhancing arthropod occurrence in wheat cropping systems: the role of non-chemical pest management and nitrogen optimization.

This study analyzes arthropod biomass and abundance to track the changes in arthropod occurrence in relation to pesticide use in three winter wheat cropping systems managed at different intensities (organic, conventional, and hybrid). Arthropod occurrence was surveyed using three collection tools: sweeping nets, eclector traps, and yellow traps. Sampling was conducted over three years from 2020 to 2022 with 588 samples collected.

Buy solar, get cashback: do consumer subsidies described as promotions influence electricity choices?

Introduction: Most countries want to make the transition to increased or even exclusive use of renewable energy. To achieve this goal, how can individuals be persuaded to use more renewable electricity? For example, does the way energy companies communicate so-called consumer subsidies matter in this regard, and if so, which communication strategy is best? For example, is a monetary promotion (e.g.