Bovine leukemia virus pre-miRNA genes' polymorphism.

MicroRNAs (miRNAs) are small non-coding RNAs with a wide distribution in nature among the living things. They play a key role both in normal signaling pathways and in pathological ones. Bovine leukemia virus (BLV) is an oncogenic retrovirus of Deltaretrovirus genus causing persistent infection in its natural hosts - cattle, zebu and water buffalo with diverse clinical manifestations through the defeat of B-lymphocytes (B-cells).

[Comprehensive assessment of the health of students with different state of the musculoskeletal system].

Priority health indices (the morbidity rate, the resistance status, the physical development, the orthopedic status, the level of bone mineralization, functional reserves of the body, health groups) in schoolchildren aged 7-18 years with a different state of the musculoskeletal system (MSS), learning in secondary schools were studied with the aim of the development of prevention programs. The high incidence of MSS diseases was determined to be combined with a high level of overall morbidity rate, on separate classes--with diseases of the nervous, endocrine, digestive systems, increasing with age ofthe student. Comprehensive assessment of health is much worse in schoolchildren with functional MSS diseases, as well as in girls.

[Polar steroids from Solaster endeca starfish and the physiological activity of polar steroids from three starfish species].

Four polyhydroxylated steroids, new (20R)-5alpha-cholestan-3beta,6alpha,8,15alpha,24,26-hexaol (I) and known (20R,25S)-5alpha-cholestan-3beta6alpha,8,15beta,16beta,26-hexaol, (20R,25S)-5alpha-cholestan-3beta,6alpha,15beta,16beta,26-pentaol, and marthasterone sulfate were isolated from the Solaster endeca starfish inhabiting the Sea of Okhotsk and characterized. Steroid (I) contains a 24,26-dihydroxylated side chain, which is uncommon for starfish polyols. The isolated steroids and related metabolites from two starfish species of the Evasterias genus (in total, 15 compounds) were weakly cytotoxic in a human HeLa cell culture and some of them were inhibitors of nonspecific esterase from mouse Ehrlich carcinoma.

[State of cellular and humoral immunity in patients with stable angina].

The article presents results of the analysis of indicators immunogenotypic tests of 104 patients with stable stenocardia I-III functional classes. It was established that patients with stable stenocardia have lower level of CD3+ T- lymphocytes, decreased rate of T- lymphocytes helpers/ suppressors (CD4+/CD8+) and increased concentration of circulating immune complexes. These changes did not depend from Functional class of stenocardia and old myocardial infarction.

[Connection of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease].

The authors presents in the article information on influence of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease (IHD). 104 male patients aged from 36 to 69 (on average 54.9+/-2.