Expression of proliferation-related genes in BM-MSC-treated ALL cells in hypoxia condition is regulated under the influence of epigenetic factors in-vitro.

Mesenchymal stem cells affect ALL cell biology under hypoxic conditions. We studied survival, proliferation, expression, and promoter methylation levels of essential genes involved in expanding MOLT-4 cells co-cultured with BM-MSC under the hypoxic condition. Here, MOLT-4 cells were co-cultured with BMMSCs under hypoxic conditions.

[Biomechanical conditions of developing injuries sustained from falling from a height].

Evaluation of the height from which human fell from his/her tissue and organ injuries is discussed. The authors of available publications paid the principal attention to estimation of the height from which the victim fell without consideration for the kinetic energy of the body, which depends not only on the height from which the victim fell, but on his/her body weight as well. Primary external and primary internal injuries are distinguished, which are determined by the area of contusion during landing; secondary contact injuries which form during inertial movement of the body after the first contusion, and injuries due to negative acceleration during contusion when landing (so-called signs of total body concussion) are also distinguished.

[Problems in biomechanics of life-time intracranial injuries].

Discusses the impact of kinetic energy and number of head movements during falling from a standing posture on one's back for various variants of falling on the formation of subdural hematomas, subarachnoidal hemorrhages, and brain concussions in the areas of the stroke, contralateral to the stroke, and intermediate. Discloses the correlations between the area and volume of injury and changes in energy parameters of stroke impact. Demonstrates the relationship between the severity of atherosclerotic involvement of the vessels and the volume and type of intracranial injury.

[Biomechanics in forensic medicine].

The paper deals with the problem in the use of biomechanics in forensic and medical practice, in the application of current biomechanical progress in the experimental investigations of the workers of the Department of Forensic Medicine, I. M. Sechenov Moscow Medical Academy.