Publications by authors named "S G Kauschke"
Article Synopsis
- This study investigates cellular senescence and its impact on aging and disease, focusing on the roles of different cell types, particularly in the context of liver injury and repair.
- Researchers created a set of genetic tools to trace and manipulate p16 cell types in vivo, revealing that macrophages and endothelial cells (ECs) have unique roles and outcomes in liver fibrosis and regeneration.
- Findings show that removing senescent macrophages helps reduce liver damage, while clearing senescent ECs worsens it; additionally, enhancing EC function through a specific gene reduces fibrosis, suggesting potential strategies for targeted therapies.
Article Synopsis
- Cirrhosis creates a proinflammatory environment, and the study aims to analyze specific inflammation patterns across various causes of compensated cirrhosis in both animal models and human patients.
- In rat models, inflammation differed based on the cirrhosis cause, with choline-deficient high-fat diet rats showing the highest proinflammatory gene expression, while in humans, different liver diseases exhibited varying levels of inflammatory markers.
- Despite common upregulation of proinflammatory pathways in all types of liver disease, the impact on fibrosis and portal hypertension varied based on the specific etiology of the disease.
Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension.
View Article and Find Full Text PDFOvereating disorders largely contribute to worldwide incidences of obesity. Available treatments are limited. Here, we discovered that long-term chemogenetic activation of ventrolateral periaqueductal gray (vlPAG) GABAergic cells rescue obesity of high-fat diet-induced obesity (DIO) mice.
View Article and Find Full Text PDFThere is a high need for predictive human ex vivo models for non-alcoholic fatty liver disease (NAFLD). About a decade ago, precision-cut liver slices (PCLSs) have been established as an ex vivo assay for humans and other organisms. In the present study, we use transcriptomics by RNASeq to profile a new human and mouse PCLSs based assay for steatosis in NAFLD.
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