Publications by authors named "S G Jordan"
Influenza A virus (IAV) infections can cause life-threatening illness in humans. The severity of disease is directly linked to virus replication in the alveoli of the lower respiratory tract. In particular, the lytic death of infected alveolar epithelial cells (AECs) is a major driver of influenza severity.
View Article and Find Full Text PDFBackground: Use of long-acting, reversible contraceptives has increased over the past 20 years, but an understanding of how they could influence cancer risk is limited.
Methods: We conducted a nested case-control study among a national cohort of Australian women (n = 176 601 diagnosed with cancer between 2004 and 2013; 882 999 matched control individuals) to investigate the associations between the levonorgestrel intrauterine system, etonogestrel implants, depot-medroxyprogesterone acetate and cancer risk and compared these results with the oral contraceptive pill. We used conditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI).
Objectives: Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.
Methods: SSc patients from the EUSTAR database with ILD were included.
Background: Pathologic confirmation of lung cancer influences treatment selection for suspected early-stage lung cancer. High pre-treatment tissue confirmation rates are recommended. We sought to define management and outcomes of patients undergoing surgery for primary lung cancer in a UK multi-centre clinical trial.
View Article and Find Full Text PDFArticle Synopsis
- The use of "Wildling mice" with a natural microbiome presents a unique research tool for studying human-like immune systems, but poses challenges for animal husbandry due to their diverse microbial content.
- A specialized facility was created at Charité - Universitätsmedizin Berlin to manage these mice, incorporating unique designs and protocols for hygiene and microbiome containment.
- The study shows that "Wildling mice" develop distinct immune cell populations compared to SPF mice, suggesting that using these mice could improve the relevancy of preclinical findings for human health.