Publications by authors named "S G Harner"
Background: Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. We aimed to investigate the association between blood inflammatory parameters and asthma burden in children with moderate-to-severe asthma.
Methods: Blood inflammatory parameters (eosinophil and neutrophil counts and inflammatory mediators using multiplex immunoassay technology) were measured in children (6-17 years) with moderate-to-severe asthma from the SysPharmPediA cohort across four European countries.
Background: Approximately 10% of European children are classified as allergic to drugs. In the majority of these children, no allergy to β-lactam antibiotics (BLA) can be found. In most cases, the exanthema is caused by the infection.
View Article and Find Full Text PDFExhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study.
Am J Respir Crit Care Med
November 2024
Article Synopsis
- Early identification of poorly controlled asthma in children is crucial for improving treatment methods, and analyzing exhaled volatile organic compounds (VOCs) shows promise for this task.
- A study evaluated the effectiveness of gas chromatography-mass spectrometry to distinguish between controlled and uncontrolled pediatric asthma, using data from multiple research phases.
- Key findings revealed that specific VOCs, such as acetophenone and ethylbenzene, could differentiate asthma control levels, achieving strong accuracy in predicting outcomes based on the collected data from 196 children.
Article Synopsis
- * Researchers analyzed blood samples from 121 children with moderate-to-severe asthma to find DNAm markers linked to BDR and FeNO, using regression models to ensure accuracy while controlling for variables like age and sex.
- * They identified specific DNA markers and differential regions related to FeNO and BDR, with findings indicating associations with allergic reactions and inflammation, potentially opening avenues for better understanding and management of asthma in pediatric patients.
Article Synopsis
- Uncontrolled asthma in children can significantly affect their quality of life, and the study explores the link between the gastrointestinal microbiome and asthma control.
- Researchers analyzed fecal samples from 143 children with asthma using various methods, including machine learning, to compare the microbiomes of those with controlled versus uncontrolled asthma.
- Findings revealed specific bacteria, like Haemophilus and Veillonella, that could distinguish between the two groups, suggesting the microbiome could serve as a potential biomarker for improving asthma treatment in children.