Publications by authors named "S G Gallego"
Background: Saint Louis encephalitis virus (SLEV) re-emergence and its geographical expansion, evidenced by its emergence in previously unaffected areas, have raised significant public health concerns. We aimed to show the usefulness of haemovigilance as an effective tool to fill arboviruses surveillance gaps to track trends and identify hotspots.
Methods: Within the framework of a blood bank haemovigilance program, we performed a survey to evaluate the potential threat of circulating mosquito-borne infections for transfusion safety.
Synaptic dysfunction is recognized as an early step in the pathophysiology of parkinsonism. Several genetic mutations affecting the integrity of synaptic proteins cause or increase the risk of developing disease. We have identified a candidate causative mutation in synaptic "SH3GL2 Interacting Protein 1" (SGIP1), linked to early-onset parkinsonism in a consanguineous Arab family.
View Article and Find Full Text PDFThe quantification of pesticide dissipation in agricultural soil is challenging. In this study, we investigated atrazine biodegradation in both liquid and soil experiments bioaugmented with distinct atrazine-degrading bacterial isolates. This was achieved by combining C-mineralisation assays and compound-specific isotope analysis of atrazine.
View Article and Find Full Text PDFArticle Synopsis
- Rhabdomyosarcoma (RMS) treatment has improved, but high-risk patients still struggle with poor survival rates due to issues like PAX3/7-FOXO1 fusion proteins that cause metastasis and resistance to therapy.
- This study focused on TRIB3, a regulator of FOXO1, finding that higher TRIB3 expression in RMS tumors correlates with the fusion protein's presence and contributes to cell proliferation.
- Genetic inhibition of TRIB3 not only reduced PAX3-FOXO1 levels and affected signaling pathways but also delayed tumor growth and improved survival rates in vivo, indicating TRIB3 could be a promising therapeutic target for aggressive RMS.