Publications by authors named "S G Fomina"
Article Synopsis
- Cancer can lead to serious kidney issues in children requiring kidney replacement therapy (KRT), with a study identifying 287 pediatric KRT patients who had a history of cancer.
- The study showed that those whose cancer caused KRT had a longer wait for kidney transplantation compared to matched controls, with a median time of 2.4 years for cancer patients versus shorter times for controls.
- While childhood cancer survivors experienced increased mortality rates while on KRT (16% for group 1 and 23% for group 2) compared to controls, their long-term survival rates after kidney transplantation were similar to non-cancer patients.
Background: The aim of the current PodoNet registry analysis was to evaluate the outcome of steroid-resistant nephrotic syndrome (SRNS) in children who were not treated with intensified immunosuppression (IIS), focusing on the potential for spontaneous remission and the role of angiotensin blockade on proteinuria reduction.
Methods: Ninety-five pediatric patients who did not receive any IIS were identified in the PodoNet Registry. Competing risk analyses were performed on 67 patients with nephrotic-range proteinuria at disease onset to explore the cumulative rates of complete or partial remission or progression to kidney failure, stratified by underlying etiology (genetic vs.
[The social human health as a complex interdisciplinary problem].
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
May 2022
The preservation and promotion of population social health is one of actual global problems worldwide. The various phenomena currently associated with coronavirus pandemic, threats to individual human physical and mental health put the whole world on dangerous brink of self-destruction that actualize studying of human vital forces and human social health. The versatility of this problem is based on unity of personal vital forces, social health and social values where human is to be the highest value of state social policy.
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- Primary Coenzyme Q10 (CoQ) deficiency is an ultra-rare genetic disorder that often results in nephrotic syndrome and is linked to mutations in specific genes.
- A global study of 116 patients showed that oral CoQ supplementation can lead to a significant reduction in proteinuria (by 88% at 12 months) and better preservation of kidney function over time.
- The findings suggest that all patients with primary CoQ deficiency should receive early and long-term CoQ supplementation to slow kidney disease progression and protect other organs from damage, with few mild side effects reported.
Primary Coenzyme Q10 deficiency is a rare mitochondriopathy with a wide spectrum of organ involvement, including steroid-resistant nephrotic syndrome mainly associated with disease-causing variants in the genes COQ2, COQ6 or COQ8B. We performed a systematic literature review, PodoNet, mitoNET, and CCGKDD registries queries and an online survey, collecting comprehensive clinical and genetic data of 251 patients spanning 173 published (47 updated) and 78 new cases. Kidney disease was first diagnosed at median age 1.
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