The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in over 7 million global fatalities and billions of individuals diagnosed with COVID-19. Acute and chronic muscle impairment associated with SARS-CoV-2 infection affected a substantial number of patients, leading to the development of symptoms such as fatigue, muscle pain, and exercise intolerance. Our study introduces an animal model to improve understanding of the pathogenicity caused by SARS-CoV-2 in human skeletal muscle.
View Article and Find Full Text PDFBehav Brain Res
January 2025
Pharmacotherapy in Alcohol Withdrawal Syndrome (AWS), which is a mental disorder, generally involves benzodiazepines due to their action via GABA, but their side effects, such as excessive sedation, mental confusion and risk of dependence, are considerable. It is important to investigate the anxiolytic potential of plants such as Caryocar coriaceum, due to the presence of secondary metabolic compounds, such as isoquercitrin, capable of promoting the reduction of anxiety during AWS. We evaluated the anxiolytic-like potential of ethanolic extracts from the leaves (EEPL) and pulp (EEPP) of C.
View Article and Find Full Text PDFBackground: Wheelchair users face various health issues, such as cardiac problems, obesity, tissue deformation, and shoulder and wrist injuries. Although the subject of ergometry is known since 1912 and the mechanic of propulsion gesture and wheelchair configuration has been studied over the years, most of the equipment found in the literature are adaptations or lack the tools for standardization of techniques. This paper aims to conduct biomechanical validation of a new wheelchair ergometer (ERGO1) designed for assessing physical fitness and muscle training of the upper limbs of people with disabilities.
View Article and Find Full Text PDFWe study resonance redistribution mechanisms inside a hot vapor cell. This is achieved by pumping cesium atoms on the 6S→6P resonance and subsequently probing the velocity distribution of the 6P population by a linear absorption experiment on the 6P→16S or 6P→15D transitions at 514 nm and 512 nm, respectively. We demonstrate that despite the existence of thermalization processes, traces of the initial velocity selection, imposed by the pump, survive in hyperfine levels of the intermediate (6P) state.
View Article and Find Full Text PDFObjective: To identify new drugs that present an increased risk of causing significant damage to critically ill patients due to failure in the administration process.
Method: The systematic literature review was conducted in the PubMed, Lilacs, Scopus, Web of Science and gray literature. The year in which the study was conducted was not restricted.
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