Publications by authors named "S G Deans"
Article Synopsis
- - Parents of newborns in the NICU found genome sequencing (GS) valuable for decision-making about future care and resolving diagnostic uncertainties.
- - Most parents accepted the timing of receiving GS results, though they noted the NICU environment could be overwhelming during the process.
- - Parents indicated that GS did not negatively affect their bonding with their infants and had mixed feelings about guilt related to the results.
A Comparison of Objectively Measured Free-Living Physical Behaviour in Adults with and without Lower Limb Amputation.
Int J Environ Res Public Health
June 2023
Unlabelled: Objectively monitored free-living physical behaviours of adults with and without lower limb amputation (LLA) were compared.
Methods: 57 adults with LLA wore an activPAL3™ for 8 days. A comparison data set ( = 57) matched on gender, age and employment status was used.
Introduction: Although DNA methylation patterns are generally considered to be faithfully inherited in Arabidopsis thaliana (Arabidopsis), there is evidence of reprogramming during both male and female gametogenesis. The gynoecium is the floral reproductive organ from which the ovules develop and generate meiotically derived cells that give rise to the female gametophyte. It is not known whether the gynoecium can condition genomic methylation in the ovule or the developing female gametophyte.
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- * The study analyzed 367 infants and found that 30% had definitive or likely genetic diagnoses, with 14% receiving uncertain results; only 43% of these findings were detected through standard clinical testing.
- * The findings suggest that genome sequencing is more effective for early genetic diagnosis in infants, especially those with specific physical traits, and the study shows no diagnostic differences among racial/ethnic groups.
The plant male germline undergoes DNA methylation reprogramming, which methylates genes de novo and thereby alters gene expression and regulates meiosis. Here, we reveal the molecular mechanism underlying this reprogramming. We demonstrate that genic methylation in the male germline, from meiocytes to sperm, is established by 24-nucleotide small interfering RNAs (siRNAs) transcribed from transposons with imperfect sequence homology.
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