Shifting the paradigm on tissue removal and postoperative complications in breast reduction: A systematic review and meta-analysis.

Background: The amount of tissue resection, measured in weight per breast, in breast reduction surgery has been considered a potential risk factor for complications.

Objective: We aimed to evaluate the effect of removing >1000 g versus <1000 g of breast tissue in women with macromastia.

Methods: A systematic search was performed on Pubmed, Embase, and Cochrane in March 2024 for studies that compared resection weight >1000 g versus <1000 g in reduction mammoplasty.

Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles.

Extracellular vesicles (EVs)-mediated communication by cancer cells contributes towards the pro-tumoral reprogramming of the tumor microenvironment. Viral infection has been observed to alter the biogenesis and cargo of EVs secreted from host cells in the context of infectious biology. However, the impact of oncolytic viruses on the cargo and function of EVs released by cancer cells remains unknown.

Correction: Large-scale population disappearances and cycling in the white-lipped peccary, a tropical forest mammal.

[This corrects the article DOI: 10.1371/journal.pone.

Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells.

Metabolic reprogramming is a ubiquitous feature of transformed cells, comprising one of the hallmarks of cancer and enabling neoplastic cells to adapt to new environments. Accumulated evidence reports on the failure of some neoplastic cells to convert mannose-6-phosphate into fructose-6-phosphate, thereby impairing tumor growth in cells displaying low levels of mannose-6-phosphate isomerase (MPI). Thus, we performed functional analyses and profiled the proteome landscape and the repertoire of substrates of proteases (degradome) of melanoma cell lines with distinct mutational backgrounds submitted to treatment with mannose.