Publications by authors named "S G Bihari"
Objective: To compare the effects of fluid bolus therapy (FBT) with 20% albumin to crystalloid FBT on the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI) and its severity and duration.
Design: Secondary analysis of the multicenter, parallel-group, open-label, randomized HAS FLAIR-II trial.
Setting: Six intensive care units.
A self-regulated expiratory flow device for mechanical ventilation: a bench study.
Intensive Care Med Exp
October 2024
Article Synopsis
- The study introduces a new passive device that regulates expiratory flow, which is important because unregulated flow can lead to lung injury in patients on mechanical ventilation.
- It tested the device against various mechanical ventilation settings, finding significant reductions in peak expiratory flow, expiratory time, and dissipated energy, all of which can indicate less risk of lung injury.
- Results showed a major decrease in peak expiratory flow and dissipated energy per breath, highlighting the device's effectiveness in improving ventilation safety without needing computer control or initial triggers.
Article Synopsis
- The study investigates acute respiratory distress syndrome (ARDS) in ICU patients from Australia and New Zealand, focusing on patient characteristics and management practices during a multi-center analysis.
- Among the 200 participants, the average age was 55.5 years; notable findings included a low adherence to lung protective ventilation (only 10.5% on day one) and significant use of adjunctive therapies like systemic steroids.
- The in-hospital mortality rate by day 28 was 30.5%, highlighting the need for improved implementation of established treatment protocols in ARDS care.
The rat is a useful laboratory model for respiratory diseases. SARS-CoV-2 proteins, such as the spike (S) protein, can induce inflammation. This study has investigated the ability of the Q498Y, P499T (QP-YT) amino acid change, described in the S-protein of the mouse-adapted laboratory SARS-CoV-2 MA strain, to interact with rat angiotensin converting enzyme-2 (ACE2) and stimulate responses in rat lungs.
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