Publications by authors named "S G Angelov"
Introduction: Healthcare contributes significantly to carbon dioxide emissions, which can be reduced by promoting sustainable mobility amongst staff commuting. This study aims to investigate the national sustainable transport infrastructure for staff of healthcare facilities and utilise this data to develop a novel scoring and ranking system.
Methods: This was an empirical retrospective observational study.
Article Synopsis
- - Thoracic aortic aneurysms (TAAs) can lead to dangerous conditions like acute thoracic aortic dissections (TADs), which are linked to disruptions in transforming growth factor (TGF) β signaling.
- - This case report examines seven specific genetic variants related to TGFβ signaling that are found in individuals with heritable or early-onset aortic dissections, comparing these variants to known pathogenic variations in a genomic database.
- - The study involved analyzing the genetic data of patients with thoracic aortic diseases, applying filters for rarity and potential pathogenicity, and suggests further research is needed to understand how these variants might impact mRNA stability and SMAD4 protein function in relation to these vascular conditions
The mechanical stability of implant coatings is crucial for medical approval and transfer to clinical applications. Here, electrophoretic deposition (EPD) is a versatile coating technique, previously shown to cause significant post-surgery impedance reduction of brain stimulation platinum electrodes. However, the mechanical stability of the resulting coating has been rarely systematically investigated.
View Article and Find Full Text PDFBackground: To test the hypothesis that smooth muscle cell (SMC) TGF-β (transforming growth factor beta) signaling contributes to maintenance of aortic structure and function beyond the early postnatal period.
Methods: We deleted the TBR2 (type 2 TGF-β receptor) in SMC of 11-month-old mice (genotype -CreER, termed TBR2) and compared their ascending aorta structure and vasomotor function to controls (-CreER, termed TBR2).
Results: We confirmed loss of aortic SMC TBR2 by immunoblotting.