Publications by authors named "S Funaki"
Acute mediastinal mass syndrome after surgical biopsy of a massive anterior mediastinal tumor: a case report.
Gen Thorac Cardiovasc Surg Cases
February 2024
Article Synopsis
- Mediastinal lymphatic tumors are rare and typically have a poor prognosis, but improvements in treatment have been noted recently.
- A 25-year-old man initially diagnosed with a thymoma underwent surgery, but post-anesthesia, he experienced respiratory complications that were linked to his mediastinal mass.
- The case highlights the importance of surgical biopsy for accurate diagnosis, while also emphasizing the need to consider the risks associated with general anesthesia in patients with mediastinal tumors.
Thoracoscopic sublobar resection for congenital bronchial atresia in adults: a report of three cases.
Gen Thorac Cardiovasc Surg Cases
November 2023
Background: Congenital bronchial atresia (CBA) is a rare bronchial abnormality. Adult patients with CBA generally do not show any symptoms. Although surgical resection is the first-line treatment, the indication for the surgical intervention is controversial, especially in mildly symptomatic or asymptomatic patients.
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- The hemagglutinating virus of Japan envelope (HVJ-E) is an inactivated virus that has shown promise in treating chemotherapy-resistant malignant pleural mesothelioma (MPM) by inducing antitumor immunity.
- A phase I clinical study focused on determining a suitable dosage and evaluating the preliminary efficacy of HVJ-E, finding that higher doses resulted in better disease control rates compared to lower doses.
- The study concluded that HVJ-E is safe for patients and appears to have some antitumor activity, leading to plans for a phase II trial with higher dosages.
Article Synopsis
- Myasthenia gravis (MG) is connected to thymus abnormalities, but the specific pathologic features in the thymus are not well understood.
- This study utilized spatial transcriptome analysis to investigate thymoma (tumors of the thymus) and thymic hyperplasia (thymus enlargement) samples, revealing that most thymomas are primarily composed of cortex, while the medullary region is notably enlarged in seropositive cases.
- The research highlights that the medulla contains unique immune structures and cell types that may be critical to MG pathology, suggesting these regions are important for future understanding and treatment of the disease.