Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model.

Introduction: Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood.

Methods: One hundred eight animals were divided into 18 groups (6 animals).

Correlation between disinfection efficacy and cumulative amount of free chlorine reaching various positions during ultrasonic fogging with hypochlorite solution.

When a hypochlorite solution is ultrasonically fogged in a room, free chlorine, i.e., HOCl and OCl, reaches various positions in two forms: fine fog droplets and gaseous hypochlorous acid（HOCl）.

Effects of plant protease inhibitors (Pep-3-EcTI, Pep-BbKI, and Pep-BrTI) versus corticosteroids on inflammation, remodeling, and oxidative stress in an asthma-COPD (ACO) model.

The peptide derived from trypsin inhibitor (Pep-3-EcTI), peptide derived from kallikrein inhibitor isolated from (Pep-BbKI), and peptide modified from (Pep-BrTI) peptides exhibit anti-inflammatory and antioxidant activities, suggesting their potential for treating asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO). We compared the effects of these peptides with dexamethasone (DX) treatment in an ACO model. In this study, 11 groups of male BALB/c mice were pre-treated under different conditions, including sensitization with intraperitoneal injection and inhalation of ovalbumin (OVA), intratracheal instillation of porcine pancreatic elastase (ELA), sensitization with intraperitoneal injection, and various combinations of peptide treatments with Pep-3-EcTI, Pep-BbKI, Pep-BrTI, dexamethasone, and non-treated controls (SAL-saline).