Publications by authors named "S Fujiuchi"

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2016. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between February 2016 and August 2016 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standards Institute.

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Background: Although fluoroquinolones are considered as alternative therapies of pulmonary Mycobacterium avium complex (MAC) disease, the association between fluoroquinolone resistance and MAC genotypes in clinical isolates from individuals not previously treated for MAC infection is not fully clear.

Methods: Totals of 154 M. avium isolates and 35 Mycobacterium intracellulare isolates were obtained from treatment-naïve patients with pulmonary MAC disease at the diagnosis of MAC infection at 8 hospitals in Japan.

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Article Synopsis
  • A nationwide surveillance study on the antimicrobial susceptibility of bacterial respiratory pathogens in Japan was conducted between January 2014 and April 2015 by three medical societies.
  • The study evaluated 1534 bacterial strains obtained from diagnosed adult patients with respiratory infections, focusing on various pathogens like Staphylococcus aureus and Streptococcus pneumoniae.
  • Results indicated high resistance rates, with 43.6% of Staphylococcus aureus being methicillin-resistant and significant percentages of Haemophilus influenzae showing resistance to ampicillin.
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Background: There are limited data for direct comparisons of the efficacy of oral itraconazole (ITCZ) and oral voriconazole (VRCZ) therapy in the treatment of chronic pulmonary aspergillosis (CPA).

Methods: We conducted a retrospective, follow-up, observational study of CPA patients enrolled in 2 previous multicenter trials.

Results: Of the 273 CPA patients, 59 and 101 patients started maintenance therapy with oral ITCZ and oral VRCZ, respectively, just after the end of acute intravenous therapy in each trial.

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Article Synopsis
  • A nationwide study in Japan in 2012 focused on monitoring the antibiotic resistance of bacterial pathogens responsible for respiratory infections in adult patients.
  • A total of 1,236 bacterial strains were tested, revealing high resistance rates, including 51.3% methicillin-resistant Staphylococcus aureus and concerning levels of antibiotic resistance in other bacteria like Klebsiella pneumoniae and Pseudomonas aeruginosa.
  • The findings highlight the importance of ongoing surveillance to understand and address the increasing resistance of bacterial respiratory pathogens to antimicrobial treatments.
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