Publications by authors named "S Fricker"
Objective: Immunotherapeutic inhibition of PD-1 by systemically administered monoclonal antibodies is widely used in cancer treatment, but it may cause severe immune-related adverse events (irSAEs). Neoadjuvant PD-1 inhibition before surgery has shown promise in reducing recurrence by stimulating durable antitumor immunity. Local intratumoral (IT) immunotherapy is a potential strategy to minimize irSAEs, but antibodies have limited tumor penetration, making them less suitable for this approach.
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- Older patients with advanced hormone receptor-positive/HER2-negative breast cancer benefit from combining CDK4/6 inhibitors with standard endocrine therapy, according to recent studies.
- There is a higher risk of side effects from these inhibitors in older patients, leading to a trend of starting them on lower doses, although this practice lacks strong evidence.
- The IMPORTANT-trial aims
Article Synopsis
- - The article explores citizen science initiatives, specifically focusing on Mozzie Monitors, which aims to gather data on mosquito populations while educating participants, revealing a need for sustainable benefits for citizen scientists.
- - Participants, mostly educated women over 50, showed significant learning outcomes, such as improved skills in mosquito species identification and photography, after engaging in the program.
- - The study found that the program not only enhanced participants' knowledge and confidence but also led to behavioral changes, like actively searching for mosquito eggs and larvae in their surroundings, contributing to better public health efforts.
Article Synopsis
- The study investigates the complex interactions of various vector and host factors that influence the transmission dynamics of the Ross River virus (RRV), Australia's leading mosquito-borne illness.
- Using mathematical modeling and long-term surveillance data from 1991 to 2017, researchers analyzed the effects of different mosquito species, host animals, and seasonal changes on RRV spread across multiple regions.
- The results reveal that combining two mosquito species and two host types, along with adjusting for seasonal variations, best explains RRV transmission dynamics, while also highlighting significant underreporting of infections.