Unraveling the genetic basis of subclinical atherosclerosis: Early genetic detection can improve cardiovascular prevention.

Introduction And Objectives: Decoding the genetic basis of coronary artery disease (CAD) through an intermediate phenotype - coronary calcification - can help us to better understand this deadly disease and enable the creation of better therapeutic strategies. This work aims to assess the relationship between a set of single nucleotide polymorphisms (SNPs) previously associated with CAD and coronary artery calcium (CAC) score in a Portuguese asymptomatic population.

Methods: A prospective study was conducted in a cohort of 1284 subjects (aged 59.

Hamstring Muscle Stiffness During Isometric Contractions Until Task Failure in Footballers With and Without Injury History.

Martínez-Serrano, A, Radaelli, R, Trindade de Freitas, T, Alcaraz, PE, and Freitas, SR. Hamstring muscle stiffness during isometric contractions until task failure in footballers with and without injury history. J Strength Cond Res XX(X): 000-000, 2024-Despite various proposed prevention strategies, the incidence of hamstring injuries in modern soccer is still elevated.

Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium LEGE 07179.

Recent analyses of genome data indicate that members of the cyanobacterial order Pleurocapsales show tremendous potential for natural product discovery. However, only a few compounds have been reported from this order. Here, we report the isolation of hyellamide (), a glycosylated N-acyl tyrosine-derived eneamide, from the pleurocapsalean cyanobacterium LEGE 07179.

The Influence of Cyanidin-3-Glucoside on the Modulation of Immune Cell Responses by Mesenchymal Stem Cell-Conditioned Medium.

Mesenchymal stem cells (MSCs) are emerging as promising therapeutic agents due to their immunomodulatory effects, primarily mediated via paracrine signaling. Similarly, anthocyanins, such as cyanidin-3-glucoside (C3G), have demonstrated significant anti-inflammatory properties. In this context, this study investigated the immunomodulatory potential of C3G on MSCs, and subsequent effects on macrophage and lymphocyte responses.

Calcifying odontogenic cyst: A detailed international multicentric study.

Objective: To elucidate the histopathological, immunohistochemical, and ultrastructural characteristics of a large series of calcifying odontogenic cysts (COCs).

Study Design: This was a multicenter cross-sectional retrospective study of seven oral pathology department laboratories from four countries. Clinical, demographic, and radiographic data of the patients were collected.