A sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain.

Caves are primary sites for studying human and animal subsistence patterns and genetic ancestry throughout the Palaeolithic. Iberia served as a critical human and animal refugium in Europe during the Last Glacial Maximum (LGM), 26.5 to 19 thousand years before the present (cal kya).

Bone quality relies on hyaluronan synthesis - Insights from mice with complete knockout of hyaluronan synthase expression.

Bone consists of a complex mineralised matrix that is maintained by a controlled equilibrium of synthesis and resorption by different cell types. Hyaluronan (HA) is an important glycosaminoglycan in many tissues including bone. Previously, the importance of HA synthesis for bone development during embryogenesis has been shown.

Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds.

Chronic non-healing wounds are characterized by persistent inflammation, excessive matrix-degrading proteolytic activity and compromised extracellular matrix (ECM) synthesis. Previous studies showed that S100A8/A9 are strongly dysregulated in delayed wound healing and impair the proper function of immune cells. Here, we demonstrate an unrecognized pathological function of overexpression in wounds with impaired healing that directly affects ECM functions in fibroblasts.

Small field chaos in spin glasses: Universal predictions from the ultrametric tree and comparison with numerical simulations.

Replica symmetry breaking (RSB) for spin glasses predicts that the equilibrium configuration at two different magnetic fields are maximally decorrelated. We show that this theory presents quantitative predictions for this chaotic behavior under the application of a external magnetic field, in the crossover region where the field intensity scales proportionally to [Formula: see text], being the system size. We show that RSB theory provides universal predictions for chaotic behavior: They depend only on the zero-field overlap probability function [Formula: see text] and are independent of other system features.