Publications by authors named "S Franceschi"
Gatemons are superconducting qubits resembling transmons, with a gate-tunable semiconducting weak link as the Josephson element. Here, we report a gatemon device featuring an aluminum microwave circuit on a Ge/SiGe heterostructure embedding a Ge quantum well. Owing to the superconducting proximity effect, the high-mobility two-dimensional hole gas confined in this well provides a gate-tunable superconducting weak link between two Al contacts.
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- Glioblastoma (GBM) is a highly aggressive brain cancer with few treatment options, and the study focuses on exploring extracellular vesicles (EVs) from GBM cells as potential diagnostic biomarkers.
- * The research utilized tumor explants from GBM patients to preserve tumor characteristics and successfully isolated EVs, analyzing their surface markers through advanced techniques.
- * Results showed unique surface biomarker expression patterns in GBM-derived EVs that could differentiate them from healthy controls, indicating their potential role in noninvasive diagnosis and understanding of GBM progression.
Glioblastoma, a deadly brain tumor, shows limited response to standard therapies like temozolomide (TMZ). Recent findings from the REGOMA trial underscore a significant survival improvement offered by Regorafenib (REGO) in recurrent glioblastoma. Our study aimed to propose a 3D ex vivo drug response precision medicine approach to investigate recurrent glioblastoma sensitivity to REGO and elucidate the underlying molecular mechanisms involved in tumor resistance or responsiveness to treatment.
View Article and Find Full Text PDFThyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls.
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- The study analyzed data from over 1 million women across various regions to explore the relationship between reproductive and hormonal factors and the risk of differentiated thyroid cancer (DTC).
- Findings indicated that certain factors, such as younger age at menarche and menopause, use of hormone therapy, and previous surgeries like hysterectomy, were associated with an increased risk of DTC, while long-term oral contraceptive use and being post-menopausal were linked to a lower risk.
- The researchers caution that the associations identified are relatively weak and recommend further studies to clarify the effects of sex steroid hormones on DTC risk.